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-synuclein, that is a primary ingredient of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that's an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) worry, counsel that dysfunction in the intracellular proteinase systems, for instance ubiquitin-proteasome system or lysosomal program, which eliminates pointless toxic prot